Speciation of Gd-based MRI contrast agents and potential products of transmetalation with iron ions or parenteral iron supplements.


The risk of transmetalation reactions between gadolinium complexes used as contrast agents for magnetic resonance imaging (MRI) and iron ions is examined under physiological conditions. A fast separation of gadopentetate (Gd-DTPA) and gadoterate (Gd-DOTA) and the respective Fe transmetalation products was accomplished by high-performance liquid… (More)
DOI: 10.1007/s00216-012-6404-x


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