Specialized inhibitory synaptic actions between nearby neocortical pyramidal neurons.

@article{Ren2007SpecializedIS,
  title={Specialized inhibitory synaptic actions between nearby neocortical pyramidal neurons.},
  author={Ming Ren and Yumiko Yoshimura and Naoki Takada and Shoko Horibe and Y. Komatsu},
  journal={Science},
  year={2007},
  volume={316 5825},
  pages={758-61}
}
We found that, in the mouse visual cortex, action potentials generated in a single layer-2/3 pyramidal (excitatory) neuron can reliably evoke large, constant-latency inhibitory postsynaptic currents in other nearby pyramidal cells. This effect is mediated by axo-axonic ionotropic glutamate receptor-mediated excitation of the nerve terminals of inhibitory interneurons, which connect to the target pyramidal cells. Therefore, individual cortical excitatory neurons can generate inhibition… CONTINUE READING

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We found that , in the mouse visual cortex , action potentials generated in a single layer-2/3 pyramidal ( excitatory ) neuron can reliably evoke large , constant - latency inhibitory postsynaptic currents in other nearby pyramidal cells .
This effect is mediated by axo - axonic ionotropic glutamate receptor - mediated excitation of the nerve terminals of inhibitory interneurons , which connect to the target pyramidal cells .
This effect is mediated by axo - axonic ionotropic glutamate receptor - mediated excitation of the nerve terminals of inhibitory interneurons , which connect to the target pyramidal cells .
We found that , in the mouse visual cortex , action potentials generated in a single layer-2/3 pyramidal ( excitatory ) neuron can reliably evoke large , constant - latency inhibitory postsynaptic currents in other nearby pyramidal cells .
We found that , in the mouse visual cortex , action potentials generated in a single layer-2/3 pyramidal ( excitatory ) neuron can reliably evoke large , constant - latency inhibitory postsynaptic currents in other nearby pyramidal cells .
We found that , in the mouse visual cortex , action potentials generated in a single layer-2/3 pyramidal ( excitatory ) neuron can reliably evoke large , constant - latency inhibitory postsynaptic currents in other nearby pyramidal cells .
We found that , in the mouse visual cortex , action potentials generated in a single layer-2/3 pyramidal ( excitatory ) neuron can reliably evoke large , constant - latency inhibitory postsynaptic currents in other nearby pyramidal cells .
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