Special regulatory T-cell review: T-cell dependent suppression revisited.

  title={Special regulatory T-cell review: T-cell dependent suppression revisited.},
  author={Antony Basten and Barbara Fazekas de St Groth},
  volume={123 1},
The concept of T-cell dependent regulation of immune responses has been a central tenet of immunological thinking since the delineation of the two cell system in the 1960s. Indeed T-cell dependent suppression was discovered before MHC restriction. When reviewing the data from the original wave of suppression, it is intriguing to reflect not just on the decline and fall of suppressor T cells in the 1980s, but on their equally dramatic return to respectability over the past decade. Hopefully… CONTINUE READING

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