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BRCAJ, a gene predisposing to breast and ovarian cancer, was mapped to chromosome 17q21 by linkage analysis. Loss of heterozy gosity In breast and ovarian tumors from BRCAJ-linked patients al ways involved loss of wild-type alleles from chromosome 17q21, sug gesting that BRCAI acts as a tumor suppressor gene. Melotic recombinatlon in linked families… (More)


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