Special HATs for special occasions: linking histone acetylation to chromatin assembly and gene activation.

@article{Brownell1996SpecialHF,
  title={Special HATs for special occasions: linking histone acetylation to chromatin assembly and gene activation.},
  author={James E. Brownell and C David Allis},
  journal={Current opinion in genetics & development},
  year={1996},
  volume={6 2},
  pages={176-84}
}
Post-translational acetylation of the core histone amino-terminal tails has long been associated with both chromatin assembly and the regulation of gene expression. The recent identification and cloning of histone acetyltransferase genes represents a significant breakthrough in our understanding of how specific acetylation states are established. Ongoing characterization of these enzymes and their molecular cohorts supports a direct role for acetylation in a signaling pathway that modulates… CONTINUE READING

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