Spatiotemporally distinct protein kinase D activation in adult cardiomyocytes in response to phenylephrine and endothelin.

@article{Bossuyt2011SpatiotemporallyDP,
  title={Spatiotemporally distinct protein kinase D activation in adult cardiomyocytes in response to phenylephrine and endothelin.},
  author={Julie Bossuyt and Chia-Wei Chang and Kathryn Helmstadter and Maya T. Kunkel and Alexandra C Newton and Kenneth S. Campbell and Jody L Martin and S. M. Bossuyt and Seth L Robia and Donald M. Bers},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 38},
  pages={33390-400}
}
Protein kinase D (PKD) is a nodal point in cardiac hypertrophic signaling. It triggers nuclear export of class II histone deacetylase (HDAC) and regulates transcription. Although this pathway is thought to be critical in cardiac hypertrophy and heart failure, little is known about spatiotemporal aspects of PKD activation at the myocyte level. Here, we demonstrate that in adult cardiomyocytes two important neurohumoral stimuli that induce hypertrophy, endothelin-1 (ET1) and phenylephrine (PE… CONTINUE READING