Spatiotemporally controlled and multifactor involved assay of neuronal compartment regeneration after chemical injury in an integrated microfluidics.

@article{Li2012SpatiotemporallyCA,
  title={Spatiotemporally controlled and multifactor involved assay of neuronal compartment regeneration after chemical injury in an integrated microfluidics.},
  author={Li Li and Li Ren and Wenming Liu and Jian-chun Wang and Yaolei Wang and Qin Tu and Juan Xu and Rui Liu and Yanrong Zhang and Mao-Sen Yuan and Tianbao Li and Jinyi Wang},
  journal={Analytical chemistry},
  year={2012},
  volume={84 15},
  pages={
          6444-53
        }
}
Studies on the degeneration and regeneration of neurons as individual compartments of axons or somata can provide critical information for the clinical therapy of nervous system diseases. A controllable in vitro platform for multiple purposes is key to such studies. In the present study, we describe an integrated microfluidic device designed for achieving localized stimulation to neuronal axons or somata. We observed neuronal compartment degeneration after localized chemical stimulation and… CONTINUE READING
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