Spatiotemporally Optimal Fractionation in Radiotherapy

Abstract

We present a spatiotemporally integrated formulation of the optimal fractionation problem using the standard log-linear-quadratic survival model. Our objective is to choose a fluencemap and a number of fractions so as to maximize the biological effect of tumor dose averaged over its voxels subject to maximum dose, mean dose, and dose-volume constraints for… (More)
DOI: 10.1287/ijoc.2016.0740

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