Spatiotemporally Controlled Co-delivery of Anti-vasculature Agent and Cytotoxic Drug by Octreotide-Modified Stealth Liposomes

Abstract

Both combretastatin A-4 (CA-4) and doxorubicin (DOX) was loaded in different form in a targeted nanomedicine in order to achieve the active delivery of these two drugs followed by sequentially suppressing tumor vasculature and tumor cells. Octreotide-modified stealth liposomes loaded with CA-4 and DOX (Oct-L[CD]) were prepared and characterized. Then in… (More)
DOI: 10.1007/s11095-012-0797-2

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@article{Dai2012SpatiotemporallyCC, title={Spatiotemporally Controlled Co-delivery of Anti-vasculature Agent and Cytotoxic Drug by Octreotide-Modified Stealth Liposomes}, author={Wenbing Dai and Wu Jin and Junlin Zhang and Xueqing Wang and Jiancheng Wang and Xuan Zhang and You Wan and Qiang Zhang}, journal={Pharmaceutical Research}, year={2012}, volume={29}, pages={2902-2911} }