Spatiotemporal transition to conduction block in canine ventricle.

@article{Fox2002SpatiotemporalTT,
  title={Spatiotemporal transition to conduction block in canine ventricle.},
  author={Jeffrey J. Fox and Mark L. Riccio and Fei Hua and Eberhard Bodenschatz and Robert F. Gilmour},
  journal={Circulation research},
  year={2002},
  volume={90 3},
  pages={
          289-96
        }
}
Interruption of periodic wave propagation by the nucleation and subsequent disintegration of spiral waves is thought to mediate the transition from normal sinus rhythm to ventricular fibrillation. This sequence of events may be precipitated by a period doubling bifurcation, manifest as a beat-to-beat alternation, or alternans, of cardiac action potential duration and conduction velocity. How alternans causes the local conduction block required for initiation of spiral wave reentry remains… CONTINUE READING

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