Spatiotemporal regulation of Src and its substrates at invadosomes.


In the past decade, substantial progress has been made in understanding how Src family kinases regulate the formation and function of invadosomes. Invadosomes are organized actin-rich structures that contain an F-actin core surrounded by an adhesive ring and mediate invasive migration. Src kinases orchestrate, either directly or indirectly, each phase of… (More)
DOI: 10.1016/j.ejcb.2012.06.003