Spatiotemporal regulation of GLI target genes in the mammalian limb bud.

@article{Lewandowski2015SpatiotemporalRO,
  title={Spatiotemporal regulation of GLI target genes in the mammalian limb bud.},
  author={Jordan P Lewandowski and Fang Du and Shilu Zhang and Marian B Powell and Kristin N Falkenstein and Hongkai Ji and Steven A Vokes},
  journal={Developmental biology},
  year={2015},
  volume={406 1},
  pages={92-103}
}
GLI proteins convert Sonic hedgehog (Shh) signaling into a transcriptional output in a tissue-specific fashion. The Shh pathway has been extensively studied in the limb bud, where it helps regulate growth through a SHH-FGF feedback loop. However, the transcriptional response is still poorly understood. We addressed this by determining the gene expression patterns of approximately 200 candidate GLI-target genes and identified three discrete SHH-responsive expression domains. GLI-target genes… CONTINUE READING