Spatiotemporal patterning of EpCAM is important for murine embryonic endo- and mesodermal differentiation

Abstract

Epithelial cell adhesion molecule EpCAM is expressed in pluripotent embryonic stem cells (ESC) in vitro, but is repressed in differentiated cells, except epithelia and carcinomas. Molecular functions of EpCAM, possibly imposing such repression, were primarily studied in malignant cells and might not apply to non-pathologic differentiation. Here, we… (More)
DOI: 10.1038/s41598-018-20131-8

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