Spatiotemporal patterning during T cell activation is highly diverse.

  title={Spatiotemporal patterning during T cell activation is highly diverse.},
  author={Kentner L. Singleton and Kole T. Roybal and Yi Mike Sun and Guo Xiang Fu and Nicholas R J Gascoigne and Nicolai S. C. van Oers and Christoph W{\"u}lfing},
  journal={Science signaling},
  volume={2 65},
Temporal and spatial variations in the concentrations of signaling intermediates in a living cell are important for signaling in complex networks because they modulate the probabilities that signaling intermediates will interact with each other. We have studied 30 signaling sensors, ranging from receptors to transcription factors, in the physiological activation of murine ex vivo T cells by antigen-presenting cells. Spatiotemporal patterning of these molecules was highly diverse and varied with… CONTINUE READING