Spatiotemporal pattern of neuronal injury induced by DFP in rats: a model for delayed neuronal cell death following acute OP intoxication.

@article{Li2011SpatiotemporalPO,
  title={Spatiotemporal pattern of neuronal injury induced by DFP in rats: a model for delayed neuronal cell death following acute OP intoxication.},
  author={Yonggang Li and Pamela J Lein and Cuimei Liu and Donald A Bruun and Teclemichael Tewolde and Gregory Ford and Byron D Ford},
  journal={Toxicology and applied pharmacology},
  year={2011},
  volume={253 3},
  pages={261-9}
}
Organophosphate (OP) neurotoxins cause acute cholinergic toxicity and seizures resulting in delayed brain damage and persistent neurological symptoms. Testing novel strategies for protecting against delayed effects of acute OP intoxication has been hampered by the lack of appropriate animal models. In this study, we characterize the spatiotemporal pattern of cellular injury after acute intoxication with the OP diisopropylfluorophosphate (DFP). Adult male Sprague-Dawley rats received… CONTINUE READING
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