Spatiotemporal pattern and isoforms of cadherin 23 in wild type and waltzer mice during inner ear hair cell development.

@article{Lagziel2005SpatiotemporalPA,
  title={Spatiotemporal pattern and isoforms of cadherin 23 in wild type and waltzer mice during inner ear hair cell development.},
  author={Ayala Lagziel and Zubair M Ahmed and Julie M. Schultz and Robert J. Morell and Inna A. Belyantseva and Thomas B Friedman},
  journal={Developmental biology},
  year={2005},
  volume={280 2},
  pages={
          295-306
        }
}
Mutant alleles of the gene encoding cadherin 23 are associated with Usher syndrome type 1 (USH1D), isolated deafness (DFNB12) in humans, and deafness and circling behavior in waltzer (v) mice. Stereocilia of waltzer mice are disorganized and the kinocilia misplaced, indicating the importance of cadherin 23 for hair bundle development. Cadherin 23 was localized to developing stereocilia and proposed as a component of the tip link. We show that, during development of the inner ear, cadherin 23 is… CONTINUE READING
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