Spatiotemporal mathematical modelling of mutations of the dhps gene in African Plasmodium falciparum

@inproceedings{Flegg2013SpatiotemporalMM,
  title={Spatiotemporal mathematical modelling of mutations of the dhps gene in African Plasmodium falciparum},
  author={Jennifer A. Flegg and Anand P. Patil and Meera Venkatesan and Cally Roper and Inbarani Naidoo and Simon I. Hay and Carol Hopkins Sibley and Philippe J Guerin},
  booktitle={Malaria Journal},
  year={2013}
}
Plasmodium falciparum has repeatedly evolved resistance to first-line anti-malarial drugs, thwarting efforts to control and eliminate the disease and in some period of time this contributed largely to an increase in mortality. Here a mathematical model was developed to map the spatiotemporal trends in the distribution of mutations in the P. falciparum dihydropteroate synthetase (dhps) gene that confer resistance to the anti-malarial sulphadoxine, and are a useful marker for the combination of… CONTINUE READING