Spatiotemporal expression patterns of metalloproteinases and their inhibitors in the postnatal developing rat cerebellum.

@article{Vaillant1999SpatiotemporalEP,
  title={Spatiotemporal expression patterns of metalloproteinases and their inhibitors in the postnatal developing rat cerebellum.},
  author={Catherine Vaillant and Marianne Didier-Baz{\`e}s and Andrea Hutter and Marie Françoise Belin and Nicole Thomasset},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1999},
  volume={19 12},
  pages={4994-5004}
}
Matrix metalloproteinases (MMPs) are proteolytic enzymes that degrade the components of the extracellular matrix (ECM). The balance between MMPs and their inhibitors [tissue inhibitors of metalloproteinases (TIMPs)] in the pericellular environment determines the most significant proteolytic events in tissue remodeling. In vitro evidence is accumulating that these molecules may be crucial in the maturation of neural cells. Here, we investigated the in vivo expression of MMPs 2, 3, and 9 and… CONTINUE READING
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