Spatiotemporal expression of flk-1 in pulmonary epithelial cells during lung development.

@article{Ahlbrecht2008SpatiotemporalEO,
  title={Spatiotemporal expression of flk-1 in pulmonary epithelial cells during lung development.},
  author={Katrin Ahlbrecht and Judith Schmitz and Ulrike Seay and Christine Schwarz and Rita Mittnacht-Kraus and Andreas K.A. Gaumann and Rainer Viktor Haberberger and Susanne Herold and Georg Breier and Friedrich Grimminger and Werner Seeger and Robert Voswinckel},
  journal={American journal of respiratory cell and molecular biology},
  year={2008},
  volume={39 2},
  pages={
          163-70
        }
}
Vascular endothelial growth factor-A (VEGF-A) responsive effects mediated via the receptors fetal liver kinase-1 (flk-1) and fms-like tyrosine kinase (flt-1), are key processes of pulmonary vascular development. Flk-1 has been shown to be involved in early embryonic lung epithelial to endothelial crosstalk and branching morphogenesis. Recent reports suggested a role of VEGF-A in lung epithelial cell function. Based on these observations, we hypothesize that epithelial flk-1 has a unique… 
View on PubMed
doi.org
16 Citations
Background Citations
5
Methods Citations
1
Results Citations
1

Figures from this paper

16 Citations

Citation Type

Citation Type

The human lung during the embryonic period: vasculogenesis and primitive erythroblasts circulation
TLDR
The hypothesis that the initial formation of the capillary plexus around the tip of the growing airway bud occurs by vasculogenesis, probably regulated by VEGF and KDR is supported.
Regulation of lung development and regeneration by the vascular system
Blood vessels have been described a long time ago as passive circuits providing sufficient blood supply to ensure proper distribution of oxygen and nutrition. Blood vessels are mainly formed during…
Inhibiting NF-κB in the developing lung disrupts angiogenesis and alveolarization.
TLDR
The data suggest that disruption of NF-κB signaling may contribute to the pathogenesis of BPD and that enhancement of NF -κB may represent a viable therapeutic strategy to promote lung growth and regeneration in pulmonary diseases marked by impaired angiogenesis.
Conditional deletion of epithelial IKKβ impairs alveolar formation through apoptosis and decreased VEGF expression during early mouse lung morphogenesis
TLDR
Testing the hypothesis that targeted deletion of NF-κB signaling in lung epithelium would impair alveolar formation suggested that epithelial NF-β plays a critical role in earlyAlveolar development possibly through regulation of VEGF.
The role of angiogenic growth factors in organogenesis.
  • E. Crivellato
  • Biology
    The International journal of developmental biology
  • 2011
TLDR
This review article will summarize some of the recent advances in the understanding of the role of angiogenic factors and endothelial cells as effectors in organ formation.
Development of the Pulmonary Endothelium in Development of the Pulmonary Circulation: Vasculogenesis and Angiogenesis
TLDR
The cardiovascular system, comprised of the heart and blood vessels, is the first functional organ formed during embryogenesis in higher vertebrates, while in humans the cardiovascular system forms after approximately 3 weeks of development.
Vascular Endothelial Growth Factor A Promotes Vaccinia Virus Entry into Host Cells via Activation of the Akt Pathway
TLDR
It is found that vascular endothelial growth factor A (VEGF-A) augments oncolytic VV cytotoxicity and Overexpression of VEGF also enhances VV infection within tumor tissue in vivo after systemic delivery.
Prolonged mechanical ventilation with air induces apoptosis and causes failure of alveolar septation and angiogenesis in lungs of newborn mice.
TLDR
This study is the first to show that prolonged MV of developing lungs, without associated hyperoxia, can inhibit alveolar septation and angiogenesis and increase apoptosis and lung elastin, findings that could reflect stretch-induced changes in VEGF and TGFbeta signaling, as reported in CLD.
Identification of betamethasone regulated target genes and cell pathways in fetal rat lung mesenchymal fibroblasts.
TLDR
It is demonstrated that betamethasone stimulates specific genes and cellular pathways controlling cell proliferation, and extracellular matrix remodelling in lung mesenchymal fibroblasts providing a basis for betamETHasone's treatment efficacy in preterm birth.
Elimination of B-RAF in Oncogenic C-RAF-expressing Alveolar Epithelial Type II Cells Reduces MAPK Signal Intensity and Lung Tumor Growth*
TLDR
Data indicate that B-RAF is an important factor in oncogenic C- RAF-mediated tumorigenesis, and mutation of Ser-621 in C-RAf BxB abrogated in vitro the dimerization with B-raF and blocked the ability to activate the MAPK cascade.
...
1
2
...

References

SHOWING 1-10 OF 50 REFERENCES
VEGF-A signaling through Flk-1 is a critical facilitator of early embryonic lung epithelial to endothelial crosstalk and branching morphogenesis.
Expression of vascular endothelial growth factor and its receptors in the developing rat lung.
TLDR
The present studies revealed that VEGF and its two receptors are upregulated during the development of capillaries in the fetal and newborn rat lung.
Tissue interactions mediate early events in pulmonary vasculogenesis
  • S. Gebb, J. Shannon
  • Biology, Medicine
    Developmental dynamics : an official publication of the American Association of Anatomists
  • 2000
TLDR
The temporal and spatial expression of flk‐1 mRNA, which encodes an endothelial cell‐specific vascular endothelial growth factor (VEGF) receptor, is defined in fetal and neonatal rat lung to suggest that tissue interactions play an important role in growth and maintenance of the developing lung vasculature.
Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice
TLDR
The generation of mice deficient in Flk-1 by disruption of the gene using homologous recombination in embryonic stem (ES) cells is reported, indicating that FlK-1 is essential for yolk-sac blood-island formation and vasculogenesis in the mouse embryo.
Role of oxygen and vascular development in epithelial branching morphogenesis of the developing mouse lung.
TLDR
In vitro data show that a low-oxygen environment enhances branching of both distal lung epithelium and vascular tissue and that pulmonary vascular development appears to be rate limiting for epithelial branching morphogenesis.
VEGF enhances pulmonary vasculogenesis and disrupts lung morphogenesis in vivo
TLDR
expression of VEGF in the developing respiratory epithelium of transgenic mice increased growth of the pulmonary blood vessels, disrupted branching morphogenesis of the lung and inhibited Type I cell differentiation.
Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
TLDR
It is reported that Flt-1 is essential for the organization of embryonic vasculature, but is not essential for endothelial cell differentiation, and it is suggested that the FlT-1 signalling pathway may regulate normal endothelium cell-cell or cell-matrix interactions during vascular development.
High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis
Vascular endothelial growth factor co-ordinates proper development of lung epithelium and vasculature
Temporal and spatial regulation of VEGF-A controls vascular patterning in the embryonic lung.
...
1
2
3
4
5
...