Spatiotemporal differences in CXCL12 expression and cyclic AMP underlie the unique pattern of optic glioma growth in neurofibromatosis type 1.

@article{Warrington2007SpatiotemporalDI,
  title={Spatiotemporal differences in CXCL12 expression and cyclic AMP underlie the unique pattern of optic glioma growth in neurofibromatosis type 1.},
  author={Nicole M. Warrington and Bryan M. Woerner and Girish C Daginakatte and Biplab Dasgupta and Arie Perry and David H Gutmann and Joshua Rubin},
  journal={Cancer research},
  year={2007},
  volume={67 18},
  pages={8588-95}
}
Astrocytoma (glioma) formation in neurofibromatosis type 1 (NF1) occurs preferentially along the optic pathway during the first decade of life. The molecular basis for this unique pattern of gliomagenesis is unknown. Previous studies in mouse Nf1 optic glioma models suggest that this patterning results from cooperative effects of Nf1 loss in glial cells and the action of factors derived from the surrounding Nf1+/- brain. Because CXCL12 is a stroma-derived growth factor for malignant brain… CONTINUE READING

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