Spatiotemporal control of microRNA function using light-activated antagomirs.

  title={Spatiotemporal control of microRNA function using light-activated antagomirs.},
  author={Colleen M Connelly and Rajendra Uprety and James Hemphill and Alexander Deiters},
  journal={Molecular bioSystems},
  volume={8 11},
MicroRNAs (miRNAs) are small non-coding RNAs that act as post-transcriptional gene regulators and have been shown to regulate many biological processes including embryonal development, cell differentiation, apoptosis, and proliferation. Variations in the expression of certain miRNAs have been linked to a wide range of human diseases - especially cancer - and the diversity of miRNA targets suggests that they are involved in various cellular networks. Several tools have been developed to control… CONTINUE READING