Spatiotemporal control of interferon-induced JAK/STAT signalling and gene transcription by the retromer complex

Abstract

Type-I interferons (IFNs) play a key role in the immune defences against viral and bacterial infections, and in cancer immunosurveillance. We have established that clathrin-dependent endocytosis of the type-I interferon (IFN-α/β) receptor (IFNAR) is required for JAK/STAT signalling. Here we show that the internalized IFNAR1 and IFNAR2 subunits of the IFNAR… (More)
DOI: 10.1038/ncomms13476

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Cite this paper

@inproceedings{Chmiest2016SpatiotemporalCO, title={Spatiotemporal control of interferon-induced JAK/STAT signalling and gene transcription by the retromer complex}, author={Daniela Chmiest and Nanaocha Sharma and Natacha Zanin and Christine Viaris de Lesegno and Massiullah Shafaq-Zadah and Vonick Sibut and Florent Dingli and Philippe Hup{\'e} and Stephan Wilmes and Jacob Piehler and Damarys Loew and Ludger Johannes and Gideon Schreiber and Christophe Lamaze}, booktitle={Nature communications}, year={2016} }