Spatiotemporal changes of the herpes simplex virus entry receptor nectin-1 in murine brain during postnatal development

@article{Horvth2006SpatiotemporalCO,
  title={Spatiotemporal changes of the herpes simplex virus entry receptor nectin-1 in murine brain during postnatal development},
  author={Szatm{\'a}r Horv{\'a}th and E Prandovszky and Zsolt Kis and Claude Krummenacher and Roselyn J Eisenberg and Gary H Cohen and Zolt{\'a}n Janka and J{\'o}zsef Toldi},
  journal={Journal of NeuroVirology},
  year={2006},
  volume={12},
  pages={161-170}
}
Herpes simplex virus (HSV) is known to replicate within the limbic system and to alter behavior in both humans and experimental animals. However, the reason why the virus selectively damages this anatomical, developmental, and functional neural unit remains a mystery. Nor is it known why herpes simplex encephalitis fails to respect these neuroanatomical boundaries in newborns. In the present study, the authors determined the spatiotemporal changes in the distribution of the major neural entry… CONTINUE READING

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