Spatiotemporal analysis of NO production upon NMDA and tetanic stimulation of the hippocampus.

@article{Takata2005SpatiotemporalAO,
  title={Spatiotemporal analysis of NO production upon NMDA and tetanic stimulation of the hippocampus.},
  author={Norio Takata and Tokiko Harada and John A. Rose and S Kawato},
  journal={Hippocampus},
  year={2005},
  volume={15 4},
  pages={427-40}
}
Nitric oxide (NO) is a gaseous neuromessenger. Although increasing evidence reveals significant physiological effects of NO in the hippocampal synaptic plasticity, the spatial distribution of NO production has remained largely uncharacterized due to the poor development of techniques for real-time NO imaging. In this work, using a NO-reactive fluorescent dye, diaminorhodamine-4M (DAR-4M), time-dependent heterogeneous NO production is demonstrated in hippocampal slices upon N-methyl-D-aspartate… CONTINUE READING