Spatiotemporal Specificity of Neuronal Activity Directs the Modification of Receptive Fields in the Developing Retinotectal System

@article{VislayMeltzer2006SpatiotemporalSO,
  title={Spatiotemporal Specificity of Neuronal Activity Directs the Modification of Receptive Fields in the Developing Retinotectal System},
  author={Rebecca L. Vislay-Meltzer and Adam R. Kampff and Florian Engert},
  journal={Neuron},
  year={2006},
  volume={50},
  pages={101-114}
}
The precise temporal relation between pre- and postsynaptic activity modulates the strength of synaptic connections. Despite its extensive characterization in vivo and in vitro, the degree to which spike timing-dependent plasticity can shape receptive field properties is unclear. We use in vivo patch-clamp recordings of tectal neurons in developing Xenopus tadpoles to control the precise timing of action potentials with respect to the arrival of a subset of visual inputs evoked by local light… CONTINUE READING
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