Spatiotemporal Regulation of a Legionella pneumophila T4SS Substrate by the Metaeffector SidJ

@inproceedings{Jeong2015SpatiotemporalRO,
  title={Spatiotemporal Regulation of a Legionella pneumophila T4SS Substrate by the Metaeffector SidJ},
  author={Kwang Cheol Jeong and Jessica A. Sexton and Joseph P. Vogel},
  booktitle={PLoS pathogens},
  year={2015}
}
Modulation of host cell function is vital for intracellular pathogens to survive and replicate within host cells. Most commonly, these pathogens utilize specialized secretion systems to inject substrates (also called effector proteins) that function as toxins within host cells. Since it would be detrimental for an intracellular pathogen to immediately kill its host cell, it is essential that secreted toxins be inactivated or degraded after they have served their purpose. The pathogen Legionella… CONTINUE READING