Spatiotemporal Regulation of Ipl1/Aurora Activity by Direct Cdk1 Phosphorylation

@article{Zimniak2012SpatiotemporalRO,
  title={Spatiotemporal Regulation of Ipl1/Aurora Activity by Direct Cdk1 Phosphorylation},
  author={Tomasz Zimniak and Veronika Fitz and Hongwen Zhou and Fabienne Lampert and Susanne Opravil and Karl Mechtler and Peggy Stolt-Bergner and Stefan Westermann},
  journal={Current Biology},
  year={2012},
  volume={22},
  pages={787-793}
}
Oscillating cyclin-dependent kinase 1 (Cdk1) activity is the major regulator of cell-cycle progression, whereas the Aurora B kinase, as part of the chromosome passenger complex (CPC), controls critical aspects of mitosis such as chromosome condensation and biorientation on the spindle. How these kinases mechanistically coordinate their important functions is only partially understood. Here, using budding yeast, we identify a regulatory mechanism by which the Cdk1 kinase Cdc28 directly controls… CONTINUE READING