Spatiotemporal Expression of Bcl-2/Bax and Neural Cell Apoptosis in the Developing Lumbosacral Spinal Cord of Rat Fetuses with Anorectal Malformations

@article{Yang2017SpatiotemporalEO,
  title={Spatiotemporal Expression of Bcl-2/Bax and Neural Cell Apoptosis in the Developing Lumbosacral Spinal Cord of Rat Fetuses with Anorectal Malformations},
  author={Z. Yang and Yuanyuan Geng and Zhiya Yao and Huimin Jia and Y. Bai and Weilin Wang},
  journal={Neurochemical Research},
  year={2017},
  volume={42},
  pages={3160-3169}
}
  • Z. Yang, Yuanyuan Geng, +3 authors Weilin Wang
  • Published 2017
  • Biology, Medicine
  • Neurochemical Research
  • Fecal incontinence and constipation still remain the major complications after procedures for anorectal malformations (ARMs). Previous studies have demonstrated a decrease of neural cell in lumbosacral spinal cord of ARMs patients and rat models. However, the underlying mechanism remains elusive. In this study, the neural cell apoptosis and Bcl-2/Bax expression were explored during lumbosacral spinal cord development in normal and ARMs fetuses. ARMs rat fetuses were induced by treating pregnant… CONTINUE READING
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