Spatio-temporal modeling of signaling protein recruitment to EGFR

  title={Spatio-temporal modeling of signaling protein recruitment to EGFR},
  author={Ming-yu Hsieh and Shujie Yang and Mary Raymond-Stinz and Jeremy S. Edwards and Bridget S. Wilson},
  booktitle={BMC Systems Biology},
A stochastic simulator was implemented to study EGFR signal initiation in 3D with single molecule detail. The model considers previously unexplored contributions to receptor-adaptor coupling, such as receptor clustering and diffusive properties of both receptors and binding partners. The agent-based and rule-based approach permits consideration of combinatorial complexity, a problem associated with multiple phosphorylation sites and the potential for simultaneous binding of adaptors. The model… CONTINUE READING
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