Spatio-temporal electrical stimuli shape behavior of an embodied cortical network in a goal-directed learning task.

@article{Bakkum2008SpatiotemporalES,
  title={Spatio-temporal electrical stimuli shape behavior of an embodied cortical network in a goal-directed learning task.},
  author={Douglas J. Bakkum and Zenas C. Chao and Steve M. Potter},
  journal={Journal of neural engineering},
  year={2008},
  volume={5 3},
  pages={310-23}
}
We developed an adaptive training algorithm, whereby an in vitro neocortical network learned to modulate its dynamics and achieve pre-determined activity states within tens of minutes through the application of patterned training stimuli using a multi-electrode array. A priori knowledge of functional connectivity was not necessary. Instead, effective training sequences were continuously discovered and refined based on real-time feedback of performance. The short-term neural dynamics in response… CONTINUE READING
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