Spatio-temporal dynamics of chromatin containing DNA breaks.

  title={Spatio-temporal dynamics of chromatin containing DNA breaks.},
  author={Michael J. Kruhlak and Arkady Celeste and Andr{\'e} Nussenzweig},
  journal={Cell cycle},
  volume={5 17},
The cellular response to DNA breaks consists of a complex signaling network that coordinates the initial recognition of the lesion with the induction of cell cycle checkpoints and DNA repair. With DNA wrapped around histone proteins and packaged into higher order levels of chromatin structure, the detection of a single DNA break (DSB) in the genome is the molecular equivalent of finding a needle in a haystack. A recent study from our laboratory used high-resolution electron microscropy and live… CONTINUE READING