Spatio-temporal correlations can drastically change the response of a MAPK pathway.

@article{Takahashi2010SpatiotemporalCC,
  title={Spatio-temporal correlations can drastically change the response of a MAPK pathway.},
  author={Koichi Takahashi and Sorin Tanase-Nicola and Pieter Rein ten Wolde},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 6},
  pages={
          2473-8
        }
}

• Koichi Takahashi, Sorin Tanase-Nicola, Pieter Rein ten Wolde
• Published 2010 in
  Proceedings of the National Academy of Sciences…
• DOI:10.1073/pnas.0906885107

Multisite covalent modification of proteins is omnipresent in eukaryotic cells. A well-known example is the mitogen-activated protein kinase (MAPK) cascade where, in each layer of the cascade, a protein is phosphorylated at two sites. It has long been known that the response of a MAPK pathway strongly depends on whether the enzymes that modify the protein act processively or distributively. A distributive mechanism, in which the enzyme molecules have to release the substrate molecules in… CONTINUE READING

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