Spatio-temporal analysis of gene expression during aging in Drosophila melanogaster.

  title={Spatio-temporal analysis of gene expression during aging in Drosophila melanogaster.},
  author={Laurent Seroude and Ted Brummel and Pankaj Kapahi and Seymour Benzer},
  journal={Aging cell},
  volume={1 1},
The relationship between gene expression and the regulation of longevity is poorly understood. Previous studies focusing on microarray or tissue-specific changes in gene expression as a function of age have provided evidence that gene expression is a dynamic process which is regulated, even late in an organism's lifespan. Using the enhancer-trap technique, a systematic analysis of the spatio-temporal regulation of gene expression in tissues of adult Drosophila is presented. As many as 80% of… CONTINUE READING

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