Spatio-Temporal Simulation of First Pass Drug Perfusion in the Liver

  title={Spatio-Temporal Simulation of First Pass Drug Perfusion in the Liver},
  author={Lars Ole Schwen and Markus Krauss and Christoph Niederalt and Felix Gremse and Fabian Kiessling and Andrea Schenk and Tobias Preu\sser and Lars Kuepfer},
  booktitle={PLoS Computational Biology},
The liver is the central organ for detoxification of xenobiotics in the body. In pharmacokinetic modeling, hepatic metabolization capacity is typically quantified as hepatic clearance computed as degradation in well-stirred compartments. This is an accurate mechanistic description once a quasi-equilibrium between blood and surrounding tissue is established. However, this model structure cannot be used to simulate spatio-temporal distribution during the first instants after drug injection. In… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 7 times over the past 90 days. VIEW TWEETS


Publications citing this paper.
Showing 1-10 of 17 extracted citations


Publications referenced by this paper.
Showing 1-10 of 15 references

Quocmesh software library, version 1.3

  • AG Rumpf
  • Numerical Simulation,
  • 2011
1 Excerpt

A preliminary study on multiscale ELLAM schemes for transient advection-diffusion equations

  • A Cheng, K Wang, H Wang
  • Numerical Methods for Partial Differential…
  • 2010
1 Excerpt

Mathematical Problems in Image Processing, Springer, volume 147 of Applied Mathematical Sciences, chapter Image Restoration

  • G Aubert, P Kornprobst
  • pp. 65–147
  • 2006
1 Excerpt

On a monotonicity preserving Eulerian–Lagrangian localized adjoint method for advection–diffusion equations

  • T Neubauer, P Bastian
  • Advances in Water Resources
  • 2005
1 Excerpt

Solving the advection-diffusion equation with the Eulerian– Lagrangian localized adjoint method on unstructured meshes and non uniform time stepping

  • A Younes, P Ackerer
  • Journal of Computational Physics
  • 2005
1 Excerpt

Numerical Treatment of Multiphase Flows in Porous Media, Springer, volume 552 of Lecture Notes in Physics, chapter Numerical Subgrid Upscaling of Two-Phase Flow in Porous Media

  • T Arbogast
  • 2000
1 Excerpt

Similar Papers

Loading similar papers…