Spatio-Temporal Simulation of First Pass Drug Perfusion in the Liver

@inproceedings{Schwen2014SpatioTemporalSO,
  title={Spatio-Temporal Simulation of First Pass Drug Perfusion in the Liver},
  author={Lars Ole Schwen and Markus Krauss and Christoph Niederalt and Felix Gremse and Fabian Kiessling and Andrea Schenk and Tobias Preu\sser and Lars Kuepfer},
  booktitle={PLoS Computational Biology},
  year={2014}
}
The liver is the central organ for detoxification of xenobiotics in the body. In pharmacokinetic modeling, hepatic metabolization capacity is typically quantified as hepatic clearance computed as degradation in well-stirred compartments. This is an accurate mechanistic description once a quasi-equilibrium between blood and surrounding tissue is established. However, this model structure cannot be used to simulate spatio-temporal distribution during the first instants after drug injection. In… CONTINUE READING
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