Spatio–temporal VEGF and PDGF Delivery Patterns Blood Vessel Formation and Maturation

@article{Chen2006SpatiotemporalVA,
  title={Spatio–temporal VEGF and PDGF Delivery Patterns Blood Vessel Formation and Maturation},
  author={Ruth R. Chen and Eduardo A Silva and William W. Yuen and David J Mooney},
  journal={Pharmaceutical Research},
  year={2006},
  volume={24},
  pages={258-264}
}
Biological mechanisms of tissue regeneration are often complex, involving the tightly coordinated spatial and temporal presentation of multiple factors. We investigated whether spatially compartmentalized and sequential delivery of factors can be used to pattern new blood vessel formation. A porous bi-layered poly(lactide–co-glycolide) (PLG) scaffold system was used to locally present vascular endothelial growth factor (VEGF) alone in one spatial region, and sequentially deliver VEGF and… CONTINUE READING
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