Spatially restricted expression of PlOtp, a Paracentrotus lividus orthopedia-related homeobox gene, is correlated with oral ectodermal patterning and skeletal morphogenesis in late-cleavage sea urchin embryos.

@article{Bernardo1999SpatiallyRE,
  title={Spatially restricted expression of PlOtp, a Paracentrotus lividus orthopedia-related homeobox gene, is correlated with oral ectodermal patterning and skeletal morphogenesis in late-cleavage sea urchin embryos.},
  author={M. C. Di Bernardo and Stefania Castagnetti and Daniela Bellomonte and Paola Oliveri and Raffaella Melfi and Franco Palla and Giovanni Spinelli},
  journal={Development},
  year={1999},
  volume={126 10},
  pages={2171-9}
}
Several homeobox genes are expressed in the sea urchin embryo but their roles in development have yet to be elucidated. Of particular interest are homologues of homeobox genes that in mouse and Drosophila are involved in patterning the developing central nervous system (CNS). Here, we report the cloning of an orthopedia (Otp)-related gene from Paracentrotus lividus, PlOtp. Otp is a single copy zygotic gene that presents a unique and highly restricted expression pattern. Transcripts were first… CONTINUE READING

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Looking into the sea urchin embryo you can see local cell interactions regulate morphogenesis.

BioEssays : news and reviews in molecular, cellular and developmental biology • 1997

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