• Corpus ID: 29921668

Spatially-resolved Brillouin spectroscopy reveals biomechanical changes in early ectatic corneal disease and post-crosslinking in vivo.

  title={Spatially-resolved Brillouin spectroscopy reveals biomechanical changes in early ectatic corneal disease and post-crosslinking in vivo.},
  author={Peng Shao and Amira M. Eltony and Theo G. Seiler and Behrouz Tavakol and Roberto Pineda and Tobias Koller and Theo G. Seiler and Seok Hyun Yun},
  journal={arXiv: Quantitative Methods},
Mounting evidence connects the biomechanical properties of tissues to the development of eye diseases such as keratoconus, a common disease in which the cornea thins and bulges into a conical shape. However, measuring biomechanical changes in vivo with sufficient sensitivity for disease detection has proved challenging. Here, we present a first large-scale study (~200 subjects, including normal and keratoconus patients) using Brillouin light-scattering microscopy to measure longitudinal modulus… 

Figures from this paper

Brillouin microscopy: assessing ocular tissue biomechanics

Brillouin microscopy is a promising technology under commercial development at present that enables physicians to characterize the biomechanical properties of ocular tissues.

Developments in Imaging of Corneal Biomechanics

The study of corneal biomechanics has gained much momentum in the last 15 years for its potential clinical applications and gold-standard methods of measuring parameters of interest include extensiometry and rheometry, which are ex vivo, destructive, and thus of limited clinical utility.

Effects of Corneal Hydration on Brillouin Microscopy In Vivo

The ex vivo and in vivo data agree with the theoretical model and support that the effect of corneal hydration on Brillouin frequency comes predominantly from the dependence of the tissue compressibility on the water.

A Review of Structural and Biomechanical Changes in the Cornea in Aging, Disease, and Photochemical Crosslinking

This review summarizes what is known about both the changes in corneal structure and associated changes inCorneal biomechanical properties in aging, keratoconic, and photochemically crosslinked corneas.

Effectiveness of intracorneal ring segments for keratoconus.

Studies have demonstrated the short-term and long-term efficacy of ICRS implantation in patients with keratoconus and with other interventions such as contacts lens, keratoplasty, and corneal collagen cross-linking.

OPINION Brillouin microscopy: assessing ocular tissue biomechanics

ow naded rom httpsournals.lw w om /cophthalm oogy by hD M fePH KazEoum tQ fN 4a+khEZgbsIH o4XM hC yw C X1AW YQ /IlQ rH D 3z+H cjN BC nrpeeM pD 3N 8/1Z+Q W C q/6pvW R C FQ = on 051/2018



In vivo biomechanical mapping of normal and keratoconus corneas.

Corneal mechanical strength is critical to withstanding intraocular pressure and maintaining normal shape1,2. In keratoconus, the mechanical stability is compromised3, and this may lead to

Brillouin optical microscopy for corneal biomechanics.

Brillouin imaging can assess the biomechanical properties of cornea in situ with high spatial resolution and has the potential for use in clinical diagnostics and treatment monitoring.

High-Resolution Quantitative Imaging of Cornea Elasticity Using Supersonic Shear Imaging

This initial investigation evaluates the ability of ultrafast and high-resolution ultrasonic systems to provide a real-time and quantitative mapping of corneal viscoelasticity and finds the SSI technique to be in good agreement with ex vivo experiments.

Brillouin microscopy of collagen crosslinking: noncontact depth-dependent analysis of corneal elastic modulus.

Noncontact Brillouin microscopy allowed imaging and quantifying CXL-induced mechanical changes without contact in a depth-dependent manner at high spatial resolution, indicating that anterior stromal stiffening contributes the most to mechanical outcome.

Method for optical coherence elastography of the cornea.

A nondestructive optical method to assess tissue under in situ mechanical conditions with physiologic-range stress levels provides a framework for in vivo quantification of 3-D corneal elastic and viscoelastic resistance, including analogs of shear deformation and Poisson's ratio that may be relevant in the early diagnosis ofCorneal ectatic disease.

Biomechanics of corneal ectasia and biomechanical treatments.

Corneal Viscoelastic Properties from Finite-Element Analysis of In Vivo Air-Puff Deformation

A viscoelastic finite element model was built that predicts the experimental corneal deformation response to an air-puff for different conditions and shows the capability of dynamic imaging to reveal inherent biomechanical properties in vivo.

Biomechanics and wound healing in the cornea.