Corpus ID: 29921668

Spatially-resolved Brillouin spectroscopy reveals biomechanical changes in early ectatic corneal disease and post-crosslinking in vivo.

  title={Spatially-resolved Brillouin spectroscopy reveals biomechanical changes in early ectatic corneal disease and post-crosslinking in vivo.},
  author={Peng Shao and Amira M. Eltony and Theo G. Seiler and Behrouz Tavakol and Roberto Pineda and Tobias Koller and Theo G. Seiler and Seok Hyun Yun},
  journal={arXiv: Quantitative Methods},
  • Peng Shao, A. Eltony, +5 authors S. Yun
  • Published 4 February 2018
  • Biology, Physics, Mathematics
  • arXiv: Quantitative Methods
Mounting evidence connects the biomechanical properties of tissues to the development of eye diseases such as keratoconus, a common disease in which the cornea thins and bulges into a conical shape. However, measuring biomechanical changes in vivo with sufficient sensitivity for disease detection has proved challenging. Here, we present a first large-scale study (~200 subjects, including normal and keratoconus patients) using Brillouin light-scattering microscopy to measure longitudinal modulus… Expand

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