Spatially heterogeneous choroid plexus transcriptomes encode positional identity and contribute to regional CSF production.

@article{Lun2015SpatiallyHC,
  title={Spatially heterogeneous choroid plexus transcriptomes encode positional identity and contribute to regional CSF production.},
  author={Melody P. Lun and Matthew B Johnson and Kevin G. Broadbelt and Momoko Watanabe and Young-Jin Kang and Kevin F Chau and Mark W. Springel and Alexandra Malesz and Andr{\'e} M M Sousa and Mihovil Pletikos and Ta{\'i}s Adelita and Monica L. Calicchio and Yong Zhang and Michael J Holtzman and H G W Lidov and Nenad Sestan and Hanno Steen and Edwin S. Monuki and Maria K Lehtinen},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2015},
  volume={35 12},
  pages={4903-16}
}
A sheet of choroid plexus epithelial cells extends into each cerebral ventricle and secretes signaling factors into the CSF. To evaluate whether differences in the CSF proteome across ventricles arise, in part, from regional differences in choroid plexus gene expression, we defined the transcriptome of lateral ventricle (telencephalic) versus fourth ventricle (hindbrain) choroid plexus. We find that positional identities of mouse, macaque, and human choroid plexi derive from gene expression… CONTINUE READING
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