Spatially fractionated radiation induces cytotoxicity and changes in gene expression in bystander and radiation adjacent murine carcinoma cells.

@article{Asur2012SpatiallyFR,
  title={Spatially fractionated radiation induces cytotoxicity and changes in gene expression in bystander and radiation adjacent murine carcinoma cells.},
  author={Rajalakshmi S Asur and Sunil Dutta Sharma and Ching-Wei Chang and Jos{\'e} A Pe{\~n}agar{\'i}cano and Indira M Kommuru and Eduardo G. Moros and Peter M. Corry and Robert J. Griffin},
  journal={Radiation research},
  year={2012},
  volume={177 6},
  pages={751-65}
}
Radiation-induced bystander effects have been extensively studied at low doses, since evidence of bystander induced cell killing and other effects on unirradiated cells were found to be predominant at doses up to 0.5 Gy. Therefore, few studies have examined bystander effects induced by exposure to higher doses of radiation, such as spatially fractionated radiation (GRID) treatment. In the present study, we evaluate the ability of GRID treatment to induce changes in GRID adjacent (bystander… CONTINUE READING
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