Spatially distinct and functionally independent mechanisms of axonal degeneration in a model of HIV-associated sensory neuropathy.

@article{Melli2006SpatiallyDA,
  title={Spatially distinct and functionally independent mechanisms of axonal degeneration in a model of HIV-associated sensory neuropathy.},
  author={Giorgia Melli and Sanjay C. Keswani and Angela Melanie Fischer and Weiran Chen and Ahmet H{\"o}ke},
  journal={Brain : a journal of neurology},
  year={2006},
  volume={129 Pt 5},
  pages={
          1330-8
        }
}
Sensory polyneuropathies are the most frequent neurological complication of human immunodeficiency virus (HIV) infection. Distal symmetric polyneuropathy (DSP), associated with HIV infection, is characterized by length-dependent axonal degeneration of sensory fibres. In rodent dorsal root ganglia (DRG) cultures, HIV viral envelope protein gp120 results in neurotoxicity and axonal degeneration. Since it is unknown whether the axonal degeneration is a consequence of neuronal death or whether it… CONTINUE READING

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