Spatially defined EGF receptor activation reveals an F-actin-dependent phospho-Erk signaling complex.

Abstract

We investigated the association of signaling proteins with epidermal growth factor (EGF) receptors (EGFR) using biotinylated EGF bound to streptavidin that is covalently coupled in an ordered array of micron-sized features on silicon surfaces. Using NIH-3T3 cells stably expressing EGFR, we observe concentration of fluorescently labeled receptors and… (More)
DOI: 10.1016/j.bpj.2014.09.048

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