Spatially and temporally synchronized atomic force and total internal reflection fluorescence microscopy for imaging and manipulating cells and biomolecules.

@article{Kellermayer2006SpatiallyAT,
  title={Spatially and temporally synchronized atomic force and total internal reflection fluorescence microscopy for imaging and manipulating cells and biomolecules.},
  author={Mikl{\'o}s S. Z. Kellermayer and {\'A}rp{\'a}d Karsai and Andr{\'a}s Kengyel and Attila Nagy and Pasquale Bianco and Tam{\'a}s Huber and Agnes Kulcs{\'a}r and Csaba Niedetzky and Roger Proksch and L{\'a}szl{\'o} Grama},
  journal={Biophysical journal},
  year={2006},
  volume={91 7},
  pages={2665-77}
}
The atomic force microscope is a high-resolution scanning-probe instrument which has become an important tool for cellular and molecular biophysics in recent years but lacks the time resolution and functional specificities offered by fluorescence microscopic techniques. To exploit the advantages of both methods, here we developed a spatially and temporally synchronized total internal reflection fluorescence and atomic force microscope system. The instrument, which we hereby call STIRF-AFM, is a… CONTINUE READING

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