Spatial transcriptomic survey of human embryonic cerebral cortex by single-cell RNA-seq analysis

@inproceedings{Fan2018SpatialTS,
  title={Spatial transcriptomic survey of human embryonic cerebral cortex by single-cell RNA-seq analysis},
  author={Xiaoying Fan and Jinjiang Dong and Suijuan Zhong and Yuan Wei and Qian Wu and Liying Yan and Jun Yong and L. G. Sun and Xiaoye May Wang and Yangyu Zhao and Wei Wang and Jie Yan and Xiaoqun Wang and Jie Qiao and Fuchou Tang},
  booktitle={Cell Research},
  year={2018}
}
The cellular complexity of human brain development has been intensively investigated, although a regional characterization of the entire human cerebral cortex based on single-cell transcriptome analysis has not been reported. Here, we performed RNA-seq on over 4,000 individual cells from 22 brain regions of human mid-gestation embryos. We identified 29 cell sub-clusters, which showed different proportions in each region and the pons showed especially high percentage of astrocytes. Embryonic… CONTINUE READING
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