Spatial structure and diffusive dynamics from single-particle trajectories using spline analysis.

@article{Long2010SpatialSA,
  title={Spatial structure and diffusive dynamics from single-particle trajectories using spline analysis.},
  author={Brian R Long and Tania Q. Vu},
  journal={Biophysical journal},
  year={2010},
  volume={98 8},
  pages={1712-21}
}
Single-particle tracking of biomolecular probes has provided a wealth of information about intracellular trafficking and the dynamics of proteins and lipids in the cell membrane. Conventional mean-square displacement (MSD) analysis of single-particle trajectories often assumes that probes are moving in a uniform environment. However, the observed two-dimensional motion of probe particles is influenced by the local three-dimensional geometry of the cell membrane and intracellular structures… CONTINUE READING