Spatial segregation of BDNF transcripts enables BDNF to differentially shape distinct dendritic compartments.

@article{Baj2011SpatialSO,
  title={Spatial segregation of BDNF transcripts enables BDNF to differentially shape distinct dendritic compartments.},
  author={Gabriele Baj and Emiliano Leone and Moses V Chao and Enrico Tongiorgi},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 40},
  pages={16813-8}
}
BDNF is produced from many transcripts that display distinct subcellular localization, suggesting that spatially restricted effects occur as a function of genetic and physiological regulation. Different BDNF 5' splice variants give a restricted localization in the cell body or the proximal and distal compartments of dendrites; however, the functional consequences are not known. Silencing individual endogenous transcripts or overexpressing BDNF-GFP transcripts in cultured neurons demonstrated… CONTINUE READING