Spatial segregation of BDNF transcripts enables BDNF to differentially shape distinct dendritic compartments

@article{Baj2011SpatialSO,
  title={Spatial segregation of BDNF transcripts enables BDNF to differentially shape distinct dendritic compartments},
  author={Gabriele Baj and Emma Leone and M. V. Chao and Enrico Tongiorgi},
  journal={Proceedings of the National Academy of Sciences},
  year={2011},
  volume={108},
  pages={16813 - 16818}
}
  • Gabriele Baj, Emma Leone, +1 author Enrico Tongiorgi
  • Published 2011
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences
  • BDNF is produced from many transcripts that display distinct subcellular localization, suggesting that spatially restricted effects occur as a function of genetic and physiological regulation. Different BDNF 5′ splice variants give a restricted localization in the cell body or the proximal and distal compartments of dendrites; however, the functional consequences are not known. Silencing individual endogenous transcripts or overexpressing BDNF-GFP transcripts in cultured neurons demonstrated… CONTINUE READING

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