Spatial segregation of BDNF transcripts enables BDNF to differentially shape distinct dendritic compartments

@article{Baj2011SpatialSO,
  title={Spatial segregation of BDNF transcripts enables BDNF to differentially shape distinct dendritic compartments},
  author={G. Baj and E. Leone and M. Chao and E. Tongiorgi},
  journal={Proceedings of the National Academy of Sciences},
  year={2011},
  volume={108},
  pages={16813 - 16818}
}
BDNF is produced from many transcripts that display distinct subcellular localization, suggesting that spatially restricted effects occur as a function of genetic and physiological regulation. Different BDNF 5′ splice variants give a restricted localization in the cell body or the proximal and distal compartments of dendrites; however, the functional consequences are not known. Silencing individual endogenous transcripts or overexpressing BDNF-GFP transcripts in cultured neurons demonstrated… Expand
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References

SHOWING 1-10 OF 45 REFERENCES
BDNF mRNA splice variants display activity-dependent targeting to distinct hippocampal laminae
Neuronal activity regulates the developmental expression and subcellular localization of cortical BDNF mRNA isoforms in vivo
Dendritic trafficking of BDNF mRNA is mediated by translin and blocked by the G196A (Val66Met) mutation
Destabilization of Cortical Dendrites and Spines by BDNF
Activity-dependent expression of brain-derived neurotrophic factor in dendrites: Facts and open questions
BDNF release from single cells elicits local dendritic growth in nearby neurons
...
1
2
3
4
5
...