Spatial regulation of the mTORC1 system in amino acids sensing pathway.

  title={Spatial regulation of the mTORC1 system in amino acids sensing pathway.},
  author={Tsukasa Suzuki and Ken Inoki},
  journal={Acta biochimica et biophysica Sinica},
  volume={43 9},
The mammalian target of rapamycin (mTOR) is an evolutionarily conserved serine/threonine protein kinase that regulates numerous cellular processes including cell growth, proliferation, cell cycle, and autophagy. mTOR forms two different multi-protein complexes referred to as mTOR complex 1 (mTORC1) and mTORC2, and each complex exerts distinct functions exclusively. mTORC1 activity is sensitive to the selective inhibitor rapamycin, whereas mTORC2 is resistant. mTORC1 is regulated by many intra… CONTINUE READING
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Regulation of translational effectors by amino acid and mammalian target of rapamycin signaling pathways . Possible involvement Regulation of mTORC 1 in nutrient sensing pathway

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