Spatial regulation of receptor tyrosine kinases in development and cancer

@article{Casaletto2012SpatialRO,
  title={Spatial regulation of receptor tyrosine kinases in development and cancer},
  author={Jessica B. Casaletto and Andrea I McClatchey},
  journal={Nature Reviews Cancer},
  year={2012},
  volume={12},
  pages={387-400}
}
During development and tissue homeostasis, patterns of cellular organization, proliferation and movement are highly choreographed. Receptor tyrosine kinases (RTKs) have a crucial role in establishing these patterns. Individual cells and tissues exhibit tight spatial control of the RTKs that they express, enabling tissue morphogenesis and function, while preventing unwarranted cell division and migration that can contribute to tumorigenesis. Indeed, RTKs are deregulated in most human cancers and… CONTINUE READING
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