Spatial regulation of β-actin translation by Src-dependent phosphorylation of ZBP1

@article{Httelmaier2005SpatialRO,
  title={Spatial regulation of $\beta$-actin translation by Src-dependent phosphorylation of ZBP1},
  author={Stefan H{\"u}ttelmaier and Daniel Zenklusen and Marcell Lederer and Jason B. Dictenberg and Mike Lorenz and Xiuhua Meng and Gary J. Bassell and John S Condeelis and Robert H. Singer},
  journal={Nature},
  year={2005},
  volume={438},
  pages={512-515}
}
Localization of β-actin messenger RNA to sites of active actin polymerization modulates cell migration during embryogenesis, differentiation and possibly carcinogenesis. This localization requires the oncofetal protein ZBP1 (Zipcode binding protein 1), which binds to a conserved 54-nucleotide element in the 3′-untranslated region of the β-actin mRNA known as the ‘zipcode’. ZBP1 promotes translocation of the β-actin transcript to actin-rich protrusions in primary fibroblasts and neurons. It is… 
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TLDR
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RACK 1 Is a Ribosome Scaffold Protein for β-actin mRNA / ZBP 1 Complex
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RACK1 Is a Ribosome Scaffold Protein for beta-actin mRNA/ZBP1 Complex
In neurons, specific mRNAs are transported in a translationally repressed manner along dendrites or axons by transport ribonucleic-protein complexes called RNA granules. ZBP1 is one RNA binding
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TLDR
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TLDR
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TLDR
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Phosphorylation of Zipcode Binding Protein 1 Is Required for Brain-Derived Neurotrophic Factor Signaling of Local β-Actin Synthesis and Growth Cone Turning
TLDR
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