Spatial raft coalescence represents an initial step in Fc gamma R signaling.

@article{Kono2002SpatialRC,
  title={Spatial raft coalescence represents an initial step in Fc gamma R signaling.},
  author={Hajime Kono and Takeshi Suzuki and Kazuhiko Yamamoto and Masato Okada and Tadashi Yamamoto and Zen-ichiro Honda},
  journal={Journal of immunology},
  year={2002},
  volume={169 1},
  pages={193-203}
}
Characterization of lipid rafts as separated membrane microdomains consist of heterogeneous proteins suggesting that lateral assembly of rafts after Ag receptor cross-linking represents the earliest signal generating process. In line with the concept, cross-linked Ag receptors have been shown to associate with detergent-insoluble raft fraction without the aid of Src family kinases. However, it has not been established whether spatial raft coalescence could also precede Src family kinase… CONTINUE READING
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