Spatial pattern of sonic hedgehog signaling through Gli genes during cerebellum development.

@article{Corrales2004SpatialPO,
  title={Spatial pattern of sonic hedgehog signaling through Gli genes during cerebellum development.},
  author={Jomichelle D Corrales and Gina L Rocco and Sandra Blaess and Qiuxia Guo and Alexandra L. Joyner},
  journal={Development},
  year={2004},
  volume={131 22},
  pages={5581-90}
}
The cerebellum consists of a highly organized set of folia that are largely generated postnatally during expansion of the granule cell precursor (GCP) pool. Since the secreted factor sonic hedgehog (Shh) is expressed in Purkinje cells and functions as a GCP mitogen in vitro, it is possible that Shh influences foliation during cerebellum development by regulating the position and/or size of lobes. We studied how Shh and its transcriptional mediators, the Gli proteins, regulate GCP proliferation… CONTINUE READING

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